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Reproductive Physiology

Jianbo Yao

headshot of Dr. Yao

Professor of Functional Genomics 

Division of Animal & Nutritional Sciences 
Davis College of Agriculture, Natural Resources and Design 
West Virginia University 
P.O. Box 6108 
Morgantown, WV 26506-6108 
2409 Agricultural Sciences 
(304)-293-1948 
jianbo.yao@mail.wvu.edu

EDUCATION

Post Doctoral, Montreal Neurological Institute, 1997-2000 
PhD, McGill University, 1997 
MSc, Wageningen University, 1990 
BSc, Shanghai Jiao-Tong University, 1985

ANNUAL TEACHING

AgBi 514 Animal Biotechnology

RESEARCH INTERESTS

Identification and characterization of novel oocyte-expressed genes that regulate follicular development and early embryogenisis in cattle and rainbow trout.

REPRESENTATIVE PUBLICATIONS

Ma H, Weber GM, Hostuttler MA, Wei H, Wang L and  Yao J. 2015. MicroRNA expression profiles from eggs of different qualities associated with post-ovulatory ageing in rainbow trout ( Oncorhynchus mykiss).  BMC Genomics. 16:201. doi 10.1186/s12864-015-1400-0.

Tripurani SK, Wee G, Lee KB, Smith GW, Wang L and  Yao J. 2013. MicroRNA-212 post-transcriptionally regulates oocyte-specific basic-helix-loop-helix transcription factor, factor in the germline alpha (FIGLA), during bovine early embryogenesis.  PLoS ONE 8(9): e76114. doi:10.1371/journal.pone.0076114. 

Wang L, Tripurani SK, Wanna W, Rexroad III CE and  Yao J. 2013. Cloning and characterization of a novel oocyte-specific gene encoding an F-Box protein in rainbow trout (Oncorhynchus mykiss)  Reproductive Biology and Endocrinology 11:86. doi:10.1186/1477-7827-11-86. 

Salem M, Leeds TD, Vallejo RL, Palti Y. Liu S, Sabbagh A, Rexroad III CE and  Yao J. 2012. RNA-Seq identifies SNP markers for growth traits in rainbow trout.  PLoS ONE 7(5): e36264. doi:10.1371/journal.pone.0036264. 

Ma H, Hostuttler M, Wei H, Rexroad III CE and  Yao J. 2012. Characterization of the rainbow trout oocyte microRNA transcriptome.  PLoS ONE 7(6): e39649. doi:10.1371/journal.pone.0039649. 

Tripurani SK, Lee KB, Wee G, Smith GW and  Yao J. 2011. MicroRNA-196a regulates bovine newborn ovary homeobox gene (NOBOX) expression during early embryogenesis.  BMC Developmental Biology 11:25. doi:10.1186/1471-213X-11-25. 

Lingenfelter BM, Tripurani SK, Tejomurtula, J, Smith GW and  Yao J. 2011. Molecular cloning and expression of bovine nucleoplasmin 2 (NPM2): a maternal effect gene regulated by miR-181a.  Reproductive Biology and Endocrinology 9:40. doi: 10.1186/1477-7827-9-40.ss). 

Tripurani SK, Lee KB, Wang L,Wee G, Smith GW, Lee YS, Latham KE and  Yao J. 2011. A novel functional role for the oocyte-specific transcription factor newborn ovary homeobox (NOBOX) during early embryonic development in cattle.  Endocrinology152:1013-1023. 

Wang J, Salem M, Qi N, Kenney PB, Rexroad III CE and  Yao J. 2011. Molecular characterization of the MuRF genes in rainbow trout: potential role in muscle degradation.  Comparative Biochemistry and Physiology Part B 158:208-215. 

Salem M, Rexroad III CE, Wang W, Thorgaard GH and  Yao J. 2010. Characterization of the rainbow trout transcriptome using Sanger and 454-pyrosequencing approaches.  BMC Genomics 11:564. doi:10.1186/1471-2164-11-564. 

Tripurani SK, Xiao C, Salem M and  Yao J. 2010. Cloning and analysis of fetal ovary microRNAs in cattle.  Animal Reproduction Science 120:16-22. 

Salem M, Kenney PB, Rexroad III CE and  Yao J. 2010. Proteomic signature of muscle atrophy in rainbow trout.  Journal of Proteomics 73: 778-789. 

Salem M, Xiao C, Womack J, Rexroad III CE and  Yao J. 2010. A microRNA repertoire for functional genome research in rainbow trout (Oncorhynchus mykiss).  Marine Biotechnology 12:410-429. 

Wanna W, Rexroad III CE and  Yao J. 2010. Identification of a functional splice variant of 14-3-3E1 in rainbow trout.  Marine Biotechnology 12:70-80. 

Tejomurtula J, Lee KB, Tripurani SK, Smith GW and  Yao J. 2009. Role of Importin α8, a new member of the importin α family of nuclear transport proteins, in early embryonic development in cattle.  Biology of Reproduction 81:333-342. 

Ramachandra RK, Salem M, Gahr S, Rexroad III CE and  Yao J. 2008. Cloning and characterization of microRNAs from rainbow trout (Oncorhynchus mykiss): their expression during early embryonic development.  BMC Developmental Biology 8:41. doi:10.1186/1471-213X-8-41. 

Salem M, Kenney PB, Rexroad III CE and  Yao J. 2008. Development of a 37K high-density oligonucleotide microarray: a new tool for functional genome research in rainbow trout.  Journal of Fish Biology 72: 2187-2206. 

Qiu G, Rexroad III CE and  Yao J. 2008. Identification of a novel germ cell-specific mRNA-like transcript (RtGST-1) predominantly expressed in early previtellgenic oocyte in rainbow trout (oncorhynchus mykiss).  Molecular Reproduction and Development75:723-730. 

Qiu GF, Ramachandra RK, Rexroad III CE and  Yao J. 2008. Molecular characterization and expression profiles of cyclin B1, B2 and cdc2 kinase during oogenesis and spermatogenesis in rainbow trout (Oncorhynchus mykiss).  Animal Reproduction Science105:209-225. 

Bettegowda A,  Yao J, Sen A, Li Q, Lee K, Kobayashi Y, Patel OV, Coussens PM, Ireland JJ and Smith GW. 2007. JY-1, a novel oocyte-specific gene, regulates granulosa cell function and early embryonic development in cattle.  Proceedings of the National Academy of Sciences U.S.A. 104:17602-17607. 

Lingenfelter BM, Dailey RA, Inskeep EK, Vernon MW, Poole DH, Rhinehart JD and  Yao J. 2007. Microarray analysis of gene expression in granulosal cells from persistent follicles in cattle.  Animal Reproduction Science 104: 405-413. 

Salem M, Silverstein J, Rexroad III CE and  Yao J. 2007. Effect of starvation on global gene expression and proteolysis in rainbow trout (Oncorhynchus mykiss).  BMC Genomics 8:328. doi:10.1186/1471-2164-8-328. 

Ramachandra RK, Lankford SE, Weber GM, Rexroad III CE and  Yao J. 2007. Identification of OORP-T, a novel oocyte-specific gene encoding a protein with a conserved oxysterol binding protein domain in rainbow trout.  Molecular Reproduction and Development 74:502-511. 

Lingenfelter BM, Dailey RA, Inskeep EK, Vernon MW, Poole DH, Rhinehart JD and  Yao J. 2007. Changes of maternal transcripts in oocytes from persistent follicles in cattle.  Molecular Reproduction and Development 74:265-272. Lingenfelter BM, Dailey RA, Inskeep EK, Vernon MW, Poole DH, Rhinehart JD,  Yao J. Microarray analysis of gene expression in granulosal cells from persistent follicles in cattle.  Anim Reprod Sci. 2008 Mar 3;104(2-4):405-13. Epub 2007 Aug 6 

Salem M, Silverstein J, Rexroad CE 3rd,  Yao J. Effect of starvation on global gene expression and proteolysis in rainbow trout (Oncorhynchus mykiss).  BMC Genomics. 2007 Sep 19;8:328. 

Ramachandra RK, Salem M, Gahr S, Rexroad CE 3rd,  Yao J. Cloning and characterization of microRNAs from rainbow trout (Oncorhynchus mykiss): their expression during early embryonic development.  BMC Dev Biol. 2008 Apr 15;8:41. 

Bettegowda A, Patel OV, Lee KB, Park KE, Salem M,  Yao J, Ireland JJ, Smith GW. Identification of novel bovine cumulus cell molecular markers predictive of oocyte competence: functional and diagnostic implications.  Biol Reprod. 2008 Aug;79(2):301-9. Epub 2008 Apr 16. 18417713. 

Goravanahally MP, Salem M,  Yao J, Inskeep EK, Flores JA. Differential gene expression in the bovine corpus luteum during transition from early phase to midphase and its potential role in acquisition of luteolytic sensitivity to prostaglandin F2 alpha.  Biol Reprod. 2009 May;80(5):980-8. Epub 2009 Jan 21. 

Tejomurtula J, Lee KB, Tripurani SK, Smith GW,  Yao J. Role of Importin Alpha8,a New Member of the Importin Alpha Family of Nuclear Transport Proteins, in EarlyEmbryonic Development in Cattle.  Biol Reprod. 2009 May 6. [Epub ahead of print] PubMed PMID: 19420384. 

Sánchez C.C., Smith, T.P., Wiedmann, R.T., Vallejo, R.L., Salem, M,  Yao J, Rexroad C.E. 3rd. 2009. Single nucleotide polymorphism discovery in rainbow trout by deep sequencing of a reduced representation library.  BMC Genomics. 10:559. DOI:10.1186/1471-2164-10-559. 

Salem, M., Kenney, P.B., Rexroad III, C.E. and  Yao, J. 2010. Proteomic signature of muscle atrophy in rainbow trout.  Journal of Proteomics. 73: 778-789. 

Tripurani, S.K., Xiao, C., Salem, M. and  Yao, J. 2010. Cloning and analysis of fetal ovary microRNAs in cattle.  Animal Reproduction Science. 120:16-22. 

Salem, M., Rexroad III, C.E., Wang, W., Thorgaard, G.H. and  Yao, J. 2010. Characterization of the rainbow trout transcriptome using Sanger and 454-pyrosequencing approaches.  BMC Genomics. 11:564. DOI:10.1186/1471-2164-11-564. 

Tripurani, S.K., Lee, K.B., Wang, L.,Wee, G., Smith, G.W., Lee, Y.S., Latham, K.E. and  Yao, J. 2011. A Novel Functional Role for the Oocyte-Specific Transcription Factor Newborn Ovary Homeobox (NOBOX) during Early Embryonic Development in Cattle. Endocrinology. 152:1013-1023. 

Lingenfelter, B.M., Tripurani, S.K., Tejomurtula, J., Smith, G.W. and  Yao, J. 2011. Molecular cloning and expression of bovine nucleoplasmin 2 (NPM2): a maternal effect gene regulated by miR-181a.  Reproductive Biology and Endocrinology 9: 40. doi: 10.1186/1477-7827-9-40.ss). 

Tripurani, S.K., Lee, K.B., Wee, G., Smith, G.W. and  Yao, J. 2011. MicroRNA-196a regulates bovine newborn ovary homeobox gene (NOBOX) expression during early embryogenesis.  BMC Developmental Biology 11:25. doi:10.1186/1471-213X-11-25.

 

Davis College of Agriculture, Natural Resources & Design 
1168 Agricultural Sciences Building 
PO Box 6108 Morgantown, WV 26506-6108