image of goodman

Robert L. Goodman

E.J. Van Liere Professor, Chairman

Department of Physiology and Pharmacology
School of Medicine
Robert C. Byrd Health Sciences Center
1 Medical Center Dr.
P.O. Box 9229, Morgantown, WV 26506-9229
304-293-1496
bgoodman@hsc.wvu.edu

Education

Post Doctoral, University of Michigan
PhD, University of Pittsburgh, 1977
BS, Swarthmore College 1969

Research Interests

To determine the physiological role of a specific set of neurons in the arcuate nucleus containing 3 neurotransmitters that mediate the feedback actions of ovarian steroids.
To determine the changes in hypothalamic function responsible for the physiological suppression of reproduction that occurs prior to puberty and in seasonal breeders

Professional Experience

1980-present: faculty member Department of Physiology (& Pharmacology), WVU
Sabbatical leaves in Cambridge UK (1989), Nouzilly FR (1997), Melbourne AU (2007)

Grants, Awards and Recognition

NIH support for study of seasonality (1981-2014) & arcuate neurons (1997-2011)
1992: Benedum Distinguish Scholar

Recent Publications

Goodman RL, Inskeep EI 2006 Neuroendocrine Control of the Ovarian Cycle of the Sheep. In: Knobil and Neill’s Physiology of Reproduction, Third Edition (Neill JD, ed) , Elsevier, Amsterdam pp. 2389-2447

Goodman RL, Lehman MN, Smith JT, Coolen LM, de Oliveira CVR, Jafarzadehshirazi MR, Pereira A, Iqbal J, Alain Caraty A, Ciofi P, Clarke IJ 2007 Kisspeptin neurons in the arcuate nucleus of the ewe also express dynorphin A and neurokinin B. Endocrinology 148: 5752-5760

Bogusz AL, Hardy SL, Lehman MN, Connors JM, Hileman SM, Sliwowska JH, Billings HJ, McManus CJ, Valent M, Singh SR, Nestor CC, Coolen LM,  Goodman RL 2008 Evidence that -amino butyric acid is part of the neural circuit mediating estradiol negative feedback in anestrous ewes. Endocrinology 149:2762-2772

Clarke IJ, Smith JT, Caraty A,  Goodman RL, Lehman MN 2009 Kisspeptin and seasonality in sheep. Peptides 30: 154-163 PMID: 18838092

Cheng G, Coolen LM, Padmanabhan V,  Goodman RL, Lehman MN 2010 The kisspeptin /neurokinin B/dynorphin (KNDY) cell population of the arcuate nucleus: sex differences and effects of prenatal testosterone in the sheep. Endocrinology 151: 301-311 PMID: 19880810

Dupre SM, Miedzinska K, Duval CV, Yu L,  Goodman RL, Lincoln GA, Davis JR, McNeilly AS, Burt BD, Loudon A 2010 Long day response in seasonal mammals, identification of a conserved Eya3 signal, and prolactin releasing factors. Curr Biol 20: 829-835 PMID: 20434341

Goodman RL, Jansen HT, Billings HJ, Coolen LM, Lehman MN 2010 Neural systems mediating seasonal breeding in the ewe. J Neuroendocrinol 22: 674-681 PMID: 20456601

Lehman MN, Coolen LM,  Goodman RL 2010 KNDy (kisspeptin/neurokinin B/dynorphin) cells of the arcuate nucleus: a central node in the control of GnRH secretion Endocrinology 151: 3479-3489 PMID: 20501670

Lehman MN, Merkley CM, Coolen LM,  Goodman RL 2010 Anatomy of the kisspeptin neural network in mammals. Brain Res 1364: 90-102 PMID: 20858464

Lehman MN, Ladha Z, Coolen LM, Hileman SM, Connors JM,  Goodman RL 2010 Neuronal Plasticity and seasonal reproduction in sheep. Eur J Neurosci 32:2152-2164.PMID: 21143669